Chemoenzymatic synthesis of boron-containing chiral amines and amides |
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| Authors: | Leandro H Andrade Thiago Barcellos Carolina G Santiago |
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| Institution: | Institute of Chemistry, University of São Paulo Av. Prof. Lineu Prestes, 748, CEP 05508-900 São Paulo, SP, Brazil |
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| Abstract: | The first application of lipases as catalysts to obtain optically active boron-containing amines and amides is described. We studied several reaction conditions to achieve the kinetic resolution of boron-containing amines via enantioselective acylation mediated by Candida antarctica lipase B (CAL-B). Excellent enantioselectivity (E >200) and high enantiomeric excess (up to >99%) of both the remaining amines and amides were obtained. |
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