Attrition-enhanced total resolution leads to homochiral families of amino acid derivatives |
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Authors: | Michel Leeman Jesse M de Gooier Karin Boer Karen Zwaagstra Bernard Kaptein Richard M Kellogg |
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Institution: | 1. Syncom BV, Kadijk 3, 9747 AT Groningen, The Netherlands;2. DSM Innovative Synthesis BV, PO Box 18, 6160 MD Geleen, The Netherlands |
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Abstract: | The total resolution of five structurally similar racemizable amino acid derivatives, three of which have racemic crystal structures, was performed simultaneously. By enantioselective incorporation in an amino acid derivative that forms a conglomerate the other four were deracemized on attrition-induced grinding. The outcome of the resolution was random (R) or (S), but all compounds had the same absolute configuration and high enantiomeric purities. |
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