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Lipase-catalyzed kinetic resolution of racemic 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates |
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| Authors: | Jürgen Brem Monica-Ioana Toşa Csaba Paizs Anca Munceanu Dubravka Matković-Čalogović Florin-Dan Irimie |
| Affiliation: | 1. Department of Biochemistry and Biochemical Engineering, Babe?-Bolyai University of Cluj-Napoca, Ro-400028 Cluj-Napoca, Arany János 11, Romania;2. Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102A, 10000 Zagreb, Croatia |
| Abstract: | The synthesis of both enantiomers of 1-(10-alkyl-10H-phenothiazin-3-yl)ethanols and their butanoates by enantiomer-selective acylation of racemic alcohols with the lipase from Pseudomonas fluorescens (L-AK) or/and by methanolysis of the corresponding racemic esters with lipase B from Candida antarctica (CaL-B) is described. The absolute configuration of the enantiomerically pure enantiomers was determined by X-ray crystallography. |
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