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Enantioselective Michael addition of diethyl cyanomethylphosphonate to chalcones using bifunctional cinchona-derived organocatalysts: synthesis of chiral precursors of α-substituted β-aminophosphonates |
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| Authors: | Truong Son Pham László Balázs Imre Petneházy Zsuzsa Jászay |
| Institution: | 1. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary;2. Chinoin Ltd, Tó utca 1-5, H-1045 Budapest, Hungary;3. Research Group for Organic Chemical Technology, Hungarian Academy of Sciences, H-1521 Budapest, Hungary |
| Abstract: | An enantioselective Michael addition of diethyl cyanomethyl phosphonate to chalcones catalysed by bifunctional catalysts based on cinchona alkaloids has been developed, producing enantiomerically enriched cyanophosphonate precursors of α-substituted β-aminophosphonates. |
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