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Fine-tunable monodentate phosphoroamidite and aminophosphine ligands for Rh-catalyzed asymmetric hydroformylation |
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| Authors: | Javier Mazuela Oscar Pàmies Montserrat Diéguez Laetitia Palais Stephane Rosset Alexandre Alexakis |
| Institution: | 1. Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/ Marcel·lí Domingo s/n, 43007 Tarragona, Spain;2. University of Geneva, Department of Organic Chemistry, 30, quai Ernest Ansermet., 1211 Genève 4, Switzerland |
| Abstract: | A biaryl-based monophosphoroamidite L1–L4a–f and aminophosphine L5–L7a–f ligand library was screened in the Rh-catalyzed asymmetric hydroformylation of several vinylarenes and heterocyclic olefins. Our results indicate that the selectivity is strongly dependent on the ligand parameters and on the substrate type. Enantioselectivities (up to 46%) were moderate in the hydroformylation of several vinylarenes S1–S5 and promising (up to 58%) for the more challenging heterocyclic olefins S6–S9. |
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