Axially chiral phosphine–oxazoline ligands in the silver(I)-catalyzed asymmetric Mannich reaction of fluorinated aldimines with trimethylsiloxyfuran |
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| Authors: | Qian-Yi Zhao Zhi-Liang Yuan Min Shi |
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| Institution: | 1. Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China |
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| Abstract: | Axially chiral phosphine–oxazoline ligand L7, prepared from (S)-binol, was found to be a fairly effective chiral ligand in the silver(I)-catalyzed asymmetric Mannich reaction of fluorinated aldimines with trimethylsiloxyfuran to give the corresponding adducts in up to 99% yield, over 20:1 dr and 81% ee. |
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