An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid |
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| Authors: | Matthew Badland Carol A Bains Roger Howard Daniel Laity Sandra D Newman |
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| Institution: | 1. Pfizer Global Pharmaceutical Sciences, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK;2. Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK |
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| Abstract: | An improved synthesis of (1R,3S)-3-(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid from 3-aminobenzoic acid is described utilising milder and more selective conditions. Both a classical salt resolution and an enzymatic approach have been shown to give the desired compound in high selectivity. |
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