A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms |
| |
| Authors: | Nicola D’Antona Raffaele Morrone Paolo Bovicelli Giovanni Gambera David Kubáč Ludmila Martínková |
| |
| Affiliation: | 1. Istituto di Chimica Biomolecolare del CNR—UOS Catania, Via P. Gaifami 18, I-95126 Catania, Italy;2. Istituto di Chimica Biomolecolare del CNR—UOS Sassari, Traversa La Crucca 3-Baldanica, I-07040 Sassari, Italy;3. Laboratory of Biotransformation, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-142 20 Prague 4, Czech Republic |
| |
| Abstract: | A new route to synthesize cyclophellitol and epi-cyclophellitol from racemic starting materials in enantiopure forms has been developed. The synthesis involves a multi-enzymatic biotransformation pathway of the novel cyano-cyclitol (1R,4S,5R,6R)/(1S,4R,5S,6S)-4,5,6-trihydroxycyclohex-2-enecarbonitrile by a cooperative use of lipase, nitrile hydratase, and amidase. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
