Synthetic studies toward potent cytostatic macrolide rhizopodin: stereoselective synthesis of the C16-C28 fragment |
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| Authors: | Tushar Kanti Chakraborty Midde SreekanthKiran Kumar Pulukuri |
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| Institution: | a Central Drug Research Institute, CSIR, Lucknow 226 001, India
b Indian Institute of Chemical Technology, CSIR, Hyderabad 500 607, India |
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| Abstract: | A stereoselective synthesis of the C16-C28 fragment of cytostatic C2-symmetric macrolide rhizopodin is described. Enantioselective addition of a chiral thiazolidinethione derived titanium enolate to acetal, Evans’ aldol reaction, Horner-Wadsworth-Emmons reaction, and Mukaiyama aldol reaction were applied as key steps. |
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| Keywords: | Rhizopodin Cytostatic Actin polymerization Inhibitor Diolides Aldol reaction |
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