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Recyclable catalytic synthesis of substituted quinolines: copper-catalyzed heterocyclization of 1-(2-aminoaryl)-2-yn-1-ols in ionic liquids |
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| Authors: | Bartolo Gabriele Raffaella Mancuso Rosella Spina Lucia Veltri |
| Institution: | a Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy b Dipartimento di Chimica, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy c Dipartimento di Chimica, Università di Bari, 70126 Bari, Italy |
| Abstract: | A convenient and simple approach for the recyclable catalytic synthesis of substituted quinolines is presented. The method is based on CuCl2-catalyzed heterocyclization of readily available 1-(2-aminoaryl)-2-yn-1-ols in BmimBF4 as the solvent at 100 °C for 15-24 h. The solvent-catalyst system could be successfully recycled up to six times without significant loss of activity. |
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