Tosylated glycerol carbonate, a versatile bis-electrophile to access new functionalized glycidol derivatives |
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| Authors: | Jolanta Rousseau Cyril Rousseau Algirdas Ša?kus Patrick Rollin |
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| Institution: | a Kaunas University of Technology, Department of Organic Chemistry, Radvilen? st. 19, LT-50254 Kaunas, Lithuania
b ICOA-UMR 6005, Université d'Orléans, Rue de Chartres BP 6759, F-45067 Orléans, France |
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| Abstract: | The reactivity of tosylated glycerol carbonate 2 toward nucleophiles has been exploited to generate glycidol analogues protected with carbonate or carbamate groups. The activated glycerol 2 is a reasonable linking agent with thiol and alcohol nucleophiles and an excellent and selective one with primary amines, allowing efficient bis-functionalizations of glycerol. |
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