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An efficient three-component protocol for the synthesis of novel spiro-oxazinobarbiturates |
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| Authors: | Mohammad Bagher Teimouri Tayyebeh Abbasi Mohammad Reza Poor Heravi |
| Affiliation: | a Petrochemical Department, Iran Polymer and Petrochemical Institute, PO Box 14965-115, Tehran, Iran b Department of Chemistry, University of Zanjan, PO Box 45195-313, Zanjan, Iran c Department of Chemistry, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran d Department of Chemistry, Payame Noor University (PNU) of Abhar, Abhar, Zanjan, Iran |
| Abstract: | Some novel spiro-oxazinobarbiturate derivatives have been successfully synthesized in a one-pot, three-component cascade reaction from various azines (pyridine, isoquinoline, quinoline and phenanthridine), 1,3-dimethylalloxan, and several activated acetylenes (alkyl propiolates, dialkyl acetylenedicarboxylates, and butyne-2-one). The high bond forming efficiency (formation of new C-N, C-C, and C-O bonds) of this reaction makes it attractive for the synthesis of spiro-oxazinobarbiturates in a single operation. |
| Keywords: | Activated acetylenes Alloxan Azines Multicomponent reactions Spiro compounds |
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