An efficient, microwave-assisted, one-pot synthesis of indoles under Sonogashira conditions |
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Authors: | Yu Chen |
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Institution: | Department of Chemistry, Iowa State University, Ames, IA 50011, United States |
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Abstract: | A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method. |
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Keywords: | Microwave-assisted One-pot Three-component coupling Indoles Sonogashira coupling |
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