The total synthesis of psymberin |
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Authors: | Huang Xianhai Shao Ning Palani Anandan Aslanian Robert Buevich Alexei |
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Affiliation: | Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA. xianhai.huang@spcorp.com |
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Abstract: | The total synthesis of a new member of the pederin family of natural products, psymberin 1, was accomplished. Using a recently reported novel and efficient PhI(OAc)2 mediated oxidative entry to 2-(N-acylaminal)-substituted tetrahydropyrans as the key step, this total synthesis was executed in a convergent and efficient manner. The longest linear sequence of this synthesis was 22 steps starting from known 6. |
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