One-dimensional Kalman filter in a robot system for total analysis of solid dosage formulations |
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Authors: | Yuzuru Hayashi Rieko Matsuda Sumie Yoshioka Yasushi Takeda |
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Affiliation: | Division of Drugs, National Institute of Hygienic Sciences, 18-1, Kamiyoga 1-Chome, Setagaya-ku, Tokyo Japan |
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Abstract: | A one-dimensional Kalman filter for peak resolution is applied to a totally automated robot system for liquid chromatographic analysis of solid dosage formulations. Sample solutions were prepared from four tablets of clemastine fumarate (1 mg/tablet) and injected automatically at regular, short intervals onto the column by the robot system. The overlapped peaks in the resulting complicated chromatogram were resolved and evaluated quantitatively by the one-dimensional filter. The peak-resolving powers are shown to be reliable by comparison with a multidimensional Kalman filter. The applicability of the whole analytical system with the linear Kalman filter is discussed. |
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