Polarization fluoroimmunoassays for the specific determination of amphetamine and methamphetamine in urine with the abbott TDx-analyzer |
| |
| Authors: | S.A. Eremin S.V. Zaitchev A.M. Egorov A.N. Ermakov A.V. Smirnov B.N. Izotov |
| |
| Affiliation: | Department of Chemistry, Division of Chemical Enzymology, Moscow State University, Moscow 119899 U.S.S.R.;Department of Pharmacology, Division of Toxicological Chemistry, First Medical Institute, Moscow 119435 U.S.S.R. |
| |
| Abstract: | Two polarization fluoroimmunoassays for the screening of amphetamine and methamphetamine in urine were adapted for use with the Abbott TDx-Analyzer running in the automatic mode. The detection limits of amphetamine and methamphetamine in 10 μl of urine were 0.03 and 0.05 mg l?1, respectively. These assays were specific for the determination of amphetamine (cross-reactivity with methamphetamine 1%) or for the determination of methamphetamine (cross-reactivity with amphetamine 2.5%). No significant cross-reaction was observed with other drugs of abuse (ephedrine, morphine and butabarbital). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
