Photochemically induced fluorimetric determination of the antimalarial mefloquine |
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| Authors: | J. Fidanza J.J. Aaron |
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| Affiliation: | Faculté des Sciences, Centre Universitaire d''Avignon, 33 Rue Louis Pasteur, 84000 Avignon France;Institut de Topologie et de Dynamique des Systèmes, Associé au CNRS, Université Paris 7, 1 Rue Guy de la Brosse, 75005 Paris France |
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| Abstract: | Mefloquine (MQ) was determined quantitatively in pharmaceutical tablets by irradiating the MQ solution for 2–7 min with a high-pressure UV lamp, measuring simultaneously the increase in fluorescence signal at room temperature (298 K) and comparing the signal with that of a standard. The effects of several solvents (acetone, dioxane, ethanol, methanol, propan-2-ol, tetrahydrofuran, water) and “pH” on the fluorescence properties of MQ and its photochemical decomposition product were studied. The limit of detection of MQ was 50 ng ml?1. The mean overall recovery from pharmaceutical tablets was 102.3 ± 4%. |
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