D-、L-和DL-青霉胺的太赫兹时域光谱

利用太赫兹时域光谱技术(THz-TDS)对D-、L-和DL-青霉胺的研究发现, 三种样品在0.2 THz到1.8 THz波段的吸收光谱存在显著差异, 实验结果表明, THz吸收光谱能够鉴别青霉胺对映异构体, 这一特点将可以用于青霉胺药物的检测. 本文利用纯D-、L-青霉胺的THz吸收光谱, 对D-、L-青霉胺混合样品的THz吸收光谱进行拟合, 证明可以用THz光谱定量分析混合样品中D-、L-青霉胺的相对含量. 这项研究为手性药物分子检测和分析提供了新的实验方法, 也对深入了解手性药物与生物靶分子之间相互作用提供了启示.

Terahertz Time-Domain Spectroscopy of D-,L-,and DL- Penicillamines

Far-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers (D- and L- penicillamines) and their racemic compound (DL-penicillamine), which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- penicillamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule.