| New Alkaloids from the Rhizomes of Goniothalamus Griffithii |
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| 摘 要： | GoniothalamusgrghthiiHook.F.etThoms(Annonaceae)isatropicalplantdistributedinsouthChina,IndiaandThailand.InwiderangescreeningfOrantitumoragentsfromAnnonaceaeplants,thecthanolicextractofrhizomesofG.grghthiiwasfOundtohc-..activeagainstvarioushumancancercelllines.Furtherpuriflcationoftheextractyieldedthreenewalkaloids,griffithdionel,griffiazanoneA2andgriffiazanoneB3wh()scstructuresweree1ucidatedbyvariousNMRtechniques,includingHMBC,NOEexperiments.(R)-and(S)-MTPAderivativeswerepreparedtod…
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New Alkaloids from the Rhizomes of Goniothalamus Griffithii |
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| Abstract: | Three new alkaloids, griffithdionc 1, griffiazanone A 2 and griffiazanone B 3 were isolated from the rhizomes of Goniothalamus griffithii Hook. F. el. Thoms. Their structures were elucidated by analysis the spectral data (IR, UV, MS, 1 H and 13C NMR, HMBC, NOE experiment).The absolute configuration of griffithazanone A 2 was determined by Mosher's methods. |
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| Keywords: | Goniothalamus griffithii phenanthrene lactam alkaloids griffithdione griffiazadioneA and griffiazadione B |
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