Amphiphilic azopolymers capable to generate photo-sensitive micelles |
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Authors: | Ioana Moleavin Constanta Ibanescu Anca Hodorog-Rusu Ecaterina Peptu Florica Doroftei Nicolae Hurduc |
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Institution: | (1) Department of Natural and Synthetic Polymers, “Gheorghe Asachi” Technical University Iasi, Bd. Mangeron 71, 700050 Iasi, Romania; |
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Abstract: | Amphiphilic macromolecular micelles are advantageous for drug delivery applications due to the decrease of side-effects, ease
of screening drugs against degradation, long-term stability, targeted delivery and control of the amount of the released drug.
A series of amphiphilic azo-polymers having a flexible or rigid main-chain were synthesized and characterized. The presence
of chlorobenzyl side-groups allowed both the easy bonding of photo-sensitive or hydrophilic groups and good control of the
degree of substitution. The chemical structure was confirmed by 1H-NMR. The critical concentration of aggregation (CCA) was calculated using the fluorescence emission spectrum of pyrene.
The interest was focused on a preliminary study concerning the disaggregation capacity of micelles under UV irradiation. The
presence of micellar aggregates was confirmed by DLS and SEM and different organization of the amphiphilic polymers was evidenced
depending on polymers concentration and polymers structure. In low polymer concentrations in water predominantly globular
aggregates were formed. The increase in concentration increased the polydispersity index due to the fusion of micelles and
formation of associates of globular aggregates, inter-micellar associates (clusters) and vesicles.
![MediaObjects/11532_2011_102_Fig1_HTML.jpg](/content/G0427253PQM77706/MediaObjects/11532_2011_102_Fig1_HTML.jpg) |
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