A new one-pot, four-component synthesis of 1,2-amino alcohols: TiCl3/t-BuOOH-mediated radical hydroxymethylation of imines |
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| Authors: | Clerici Angelo Ghilardi Alessandra Pastori Nadia Punta Carlo Porta Ombretta |
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| Affiliation: | Dipartimento di Chimica, Materiali e Ingegneria Chimica Giulio Natta, Politecnico di Milano-Sezione Chimica, Via Mancinelli 7, 20131 Milano, Italy. |
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| Abstract: | An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields. |
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