Oxo-ester mediated native chemical ligation: concept and applications |
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| Authors: | Wan Qian Chen Jin Yuan Yu Danishefsky Samuel J |
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| Affiliation: | Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA. |
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| Abstract: | A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para nitrophenyl ester (1), it is possible to achieve direct cysteine ligations (1 + 2 --> 4). Peptide substrates incorporating bulky C-terminal amino acids (1) can be accommodated with high reaction efficiency. |
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