Linear response equilibrium |
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Authors: | Eberhardt Kai W Schär Michael Barmet Christoph Tsao Jeffrey Boesiger Peter Kozerke Sebastian |
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Institution: | Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland. |
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Abstract: | A new periodic pulse sequence employing weak excitation is presented. This type of sequence drives the system into a steady-state with periodic time evolution from which the data can be reconstructed to a spectrum. It is demonstrated that the frequency response of such a sequence can be analyzed using perturbation methods and linear system analysis. A mathematical framework is proposed allowing the frequency response to be tailored by weighting a periodic flip function. The weak excitation level used implies very low specific absorption rates while generating a highly frequency selective signal in the order of 1/T2 with signal strengths comparable to those obtainable with conventional large flip angle balanced steady-state free precession techniques. The concept is illustrated with phantom experiments and in vivo feasibility of water fat separation is shown on human knee images. |
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