Analysis of cannabinoids by liquid chromatography— Thermospray mass spectrometry and liquid chromatography— Tandem mass spectrometry |
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Authors: | K Ndjoko J -L Wolfender K Hostettmann |
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Institution: | (1) Institute de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, 1015 Lausanne, Switzerland |
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Abstract: | Summary A rapid method based on liquid chromatography and thermospray mass spectrometry without any derivatization or pre-purification
steps has been developed for the identification and quantification of cannabinoids in drugs from cannabis plants. The extracts
were separated on a C18 reversed-phase column with an acidic acetonitrile-water gradient. Liquid chromatographymass spectrometry was performed with
a thermospray interface and protonated molecular ions were obtained from the cannabinoids of interest. Liquid chromatography-tandem
mass spectrometry experiments on the molecular ions gave additional structural information online. The sensitivity and selectivity
of the method was sufficient to enable the detection of 100 pg of the cannabinoids. |
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Keywords: | Column liquid chromatography-mass spectrometry Thermospray Identification and quantification Δ 4-tetrahydrocannabinolic acid Δ 4-tetrahydrocannabinol Cannabinol Cannabidiol |
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