Preparation and characterization of nonfouling polymer brushes on poly(ethylene terephthalate) film surfaces |
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| Institution: | 1. National Research and Development Institute for Chemistry and Petrochemistry ICECHIM, Advanced Polymer Materials and Polymer Recycling, 202 Splaiul Independentei, 060021 Bucharest, Romania;2. Laboratoire MAPIEM, EA 4323, Université de Toulon, 83041 Toulon Cedex 9, France;3. University Politehnica of Bucharest, The Faculty of Applied Chemistry and Material Science, Bioresources and Polymer Science Department, 1-7 Polizu, 011061 Bucharest, Romania;1. Faculty of Science and Engineering, Manchester Metropolitan University, Chester Street, Manchester, M1 5GD, United Kingdom;2. Center of Excellence on Catalysis and Catalytic Reaction Engineering, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand;3. Molecular Science Institute, School of Chemistry, University of the Witwatersrand, P.O. Box X3, Wits, 2050, South Africa;1. Department of Cardiology, St John Of God Subiaco Hospital, Perth, Western Australia;2. Department of Microbiology, PathWest Laboratory Medicine WA, Perth, Western Australia;3. Department of Cardiothoracic Surgery, St John Of God Subiaco Hospital, Perth, Western Australia;4. Oceanic Medical Imaging, Hollywood Medical Centre, Perth, Western Australia;1. Institute of Polymer Chemistry, University of Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany;2. Institute of Textile Chemistry and Chemical Fibres, Körschtalstraße 26, D-73770 Denkendorf, Germany;3. Institute of Inorganic Chemistry, University of Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany;4. Institute of Textile Technology and Process Engineering, Körschtalstraße 26, D-73770 Denkendorf, Germany;5. Institute of Orthopaedic Research and Biomechanics, Helmholtzstraße 14, D-89081 Ulm, Germany;1. Department of Chemical and Biological Engineering, Gachon University, Seongnam 461-701, Gyeonggi, Republic of Korea;2. Department of Applied Chemistry, Dongduk Women''s University, Seoul 136-714, Republic of Korea |
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| Abstract: | In this study, a surface grafting of nonfouling poly(ethylene glycol) methyl ether acrylate (PEGMA) on poly(ethylene terephthalate) (PET) was carried out via surface-initiated atom-transfer radical polymerization (SI-ATRP) to improve hemocompatibility of polymer based biomaterials. To do this, the coupling agent with hydroxyl groups for the ATRP initiator was first anchored on the surface of PET films using photochemical method, and then these hydroxyl groups were esterified by bromoisobutyryl bromide, from which PET with various main chain lengths of PEGMA was prepared. The structures and properties of modified PET surfaces were investigated using water contact angle (WAC), ATR-FTIR, X-ray photoelectron spectroscopy (XPS) and Atomic force microscopy (AFM). The molecular weights of the free polymer from solution were determined by gel permeation chromatography (GPC). These results indicated that grafting of PEGMA on PET film is a simple way to change its surface properties. The protein adsorption resistance on the surfaces of PET was primarily evaluated by an enzyme-linked immunosorbent assay (ELISA). The result demonstrated that the protein adsorption could be well suppressed by poly(PEGMA) brush structure on the surface of PET. This work provides a new approach for polymers to enhance their biocompatibility. |
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