Silver nanoparticles impede the biofilm formation by Pseudomonas aeruginosa and Staphylococcus epidermidis |
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| Institution: | 1. Department of Microbiology, School of Life Sciences, Pondicherry University, India;2. Department of Food Science and Technology, School of Life Sciences, Pondicherry University, India;1. Assistant Professor in Biochemistry, Department of Microbiology, Idhaya College for Women (Affiliated to Bharathidasan University, Tiruchirrapalli-620024), Kumbakonam, Tamil Nadu 612001, India;2. Assistant Professor in Microbiology, Idhaya College for Women (Affiliated to Bharathidasan University, Tiruchirrapalli-620024), Kumbakonam, Tamil Nadu 612001, India;1. Department of Animal Biotechnology, Konkuk University, 1 Hwayang-Dong, Gwangin-gu, Seoul 143-701, South Korea;2. GS Institute of Bio and Nanotechnology, Coimbatore, Tamil Nadu 641024, India;1. Department of Microbiology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran;2. Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;3. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;6. Department of Medicinal Chemistry, School of Pharmacy, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;8. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;9. Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanl?, Tuzla, 34956, Istanbul, Turkey;10. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA;11. Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA;1. Crustacean Molecular Biology and Genomics Lab, Department of Animal Health and Management, Alagappa University, Science Block 4th Floor, Burma Colony, Karaikudi 630004, Tamil Nadu, India;2. Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India;3. Aqua Genetics and Biotechnology Laboratory, Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, 1 Hseuh-Fu Rd., Nei-Pu Hsiang, Pingtung 91201, Taiwan |
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| Abstract: | Biofilms are ensued due to bacteria that attach to surfaces and aggregate in a hydrated polymeric matrix. Formation of these sessile communities and their inherent resistance to anti-microbial agents are the source of many relentless and chronic bacterial infections. Such biofilms are responsible play a major role in development of ocular related infectious diseases in human namely microbial keratitis. Different approaches have been used for preventing biofilm related infections in health care settings. Many of these methods have their own demerits that include chemical based complications; emergent antibiotic resistant strains, etc. silver nanoparticles are renowned for their influential anti-microbial activity. Hence the present study over the biologically synthesized silver nanoparticles, exhibited a potential anti-biofilm activity that was tested in vitro on biofilms formed by Pseudomonas aeruginosa and Staphylococcus epidermidis during 24-h treatment. Treating these organisms with silver nanoparticles resulted in more than 95% inhibition in biofilm formation. The inhibition was known to be invariable of the species tested. As a result this study demonstrates the futuristic application of silver nanoparticles in treating microbial keratitis based on its potential anti-biofilm activity. |
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