Research and synthesis of organosilicon nonthrombogenic materials containing sulfobetaine group |
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| Institution: | 1. Institute of Microengineering and Nanoelectronics, Research Complex, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia;2. Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, University Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia;3. Centre for Sustainable Process Technology (CESPRO), Faculty of Engineering and Built Environment, University Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia;1. Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia;2. Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”, Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino, Moscow Region, Russia;3. Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Pushchino, Russia;4. Mari State University, Yoshkar-Ola, Russia;5. Bauman Moscow State Technical University, Moscow, Russia;6. MIREA - Russian Technological University, Moscow, Russia;7. The Institute of Biology and Biomedicine, Lobachevsky State University of Nizhni Novgorod, Nizhni Novgorod, Russia;8. V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia;9. All-Russian Research Institute of Phytopatology, Bol''shie Vyazemy, Russia |
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| Abstract: | A novel organosilicon sulfobetaine was synthesized through the reaction of organosilicon containing tertiary amino with 1,3-propanesulfone. Then this organosilicon sulfobetaine was coated onto polyurethane and organosilicon surface to improve their blood compatibility. The existence of sulfobetaine structure on the surface of materials was revealed by ATR-FTIR and XPS. The thermo-capability of synthesized silicone rubber, containing sulfobetaine was revealed by TGA. The blood compatibilities of organosilicon sulfobetaine and other materials such as silicone and PU as reference coated with them were evaluated by platelet-rich plasma adhesion experiment. The novel segmented silicone rubber containing sulfobetaine structure showed perfect blood compatibility. |
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