Characterization and release behaviors of porous PCL/Eudragit RS microcapsules containing tulobuterol |
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| Institution: | 1. Centre for Biomaterials and Tissue Engineering (CBIT), Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain;2. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain;1. Inserm UMR1073, Nutrition, Gut and Brain Laboratory, Rouen 76183, France;2. Institute for Research and Innovation in Biomedicine (IRIB), Rouen University, Normandy University, 76000, France;3. Rouen University Hospital, CHU Charles Nicolle, Rouen 76183, France;4. Institute of Molecular Chemistry of Reims (ICMR), UMR CNRS 7312, University of Reims Champagne-Ardenne, 51100, France;1. School of Materials Engineering, Yancheng Institute of Technology, Yancheng 224051, China;2. Key Laboratory of Eco-Textile, Ministry of Education, Jiangnan University, Wuxi 214122, China;1. ETH Zurich, Nonmetallic Inorganic Materials, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland;2. BASF SE, GK/IK-B001, 67056 Ludwigshafen, Germany |
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| Abstract: | In this work, porous poly(ɛ-caprolactone) (PCL)/Eudragit RS 100 (ERS-100) microcapsules containing tulobuterol base as a model drug were prepared by a solvent evaporation method and the effect of the quaternary ammonium groups of ERS-100 on the release behaviors of the microcapsules was investigated. The microcapsules prepared with PCL alone showed a stable and smooth surface, whereas porous microcapsules were formed with the addition of ERS-100. Drug loading and encapsulation efficiency of the microcapsules were slightly decreased with an increase of ERS-100 content, resulting from an increase in the porosity of the microcapsules. In an acidic release medium, PCL microcapsules showed slow drug release, whereas PCL/ERS-100 microcapsules showed a faster release rate with an increasing ERS-100 content. These behaviors are likely due to an increase in the diffusion rate of the drugs stemming from an increased hydration of the microcapsules, which results from the interaction between the carboxyl group of the release medium and the quaternary ammonium group of ERS-100. |
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