Graphite Micropowder Modified with 4‐Amino‐2,6‐diphenylphenol Supported on Basal Plane Pyrolytic Graphite Electrodes: Micro Sensing Platforms for the Indirect Electrochemical Detection of Δ9‐Tetrahydrocannabinol in Saliva

Graphite micropowder has been modified with 4‐amino‐2,6‐diphenylphenol immobilized onto a basal plane pyrolytic graphite electrode and explored for the indirect electrochemical sensing of Δ⁹‐tetrahydrocannabinol in artificial saliva. The protocol is based on the electrochemical formation of quinoneimine which specifically reacts with Δ⁹‐tetrahydrocannabinol resulting in the loss of the quinoneimine which can be monitored via voltammetry. It is demonstrated that Δ⁹‐tetrahydrocannabinol can be detected in artificial saliva over the micromolar range. Such a protocol may find application in screening for drug abuse.