Philinopsides A and B,Two New Sulfated Triterpene Glycosides from the Sea Cucumber Pentacta quadrangularis |
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| Authors: | Yang‐Hua Yi,Qiang‐Zhi Xu,Ling Li,Shi‐Long Zhang,Hou‐Ming Wu,Jian Ding,Yun‐Guang Tong,Wen‐Fu Tan,Mei‐Hong Li,Fang Tian,Jiu‐Hong Wu,Chih‐Chuang Liaw,Kenneth&#x F. Bastow,Kuo‐Hsiung Lee |
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| Affiliation: | Yang‐Hua Yi,Qiang‐Zhi Xu,Ling Li,Shi‐Long Zhang,Hou‐Ming Wu,Jian Ding,Yun‐Guang Tong,Wen‐Fu Tan,Mei‐Hong Li,Fang Tian,Jiu‐Hong Wu,Chih‐Chuang Liaw,Kenneth F. Bastow,Kuo‐Hsiung Lee |
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| Abstract: | Two new sulfated triterpene glycosides, philinopsides A ( 1 ) and B ( 2 ), were isolated from the sea cucumber Pentacta quadrangularis. Their structures were established by extensive spectral analysis (2D‐NMR and MS) and chemical evidence. Philinopside A ( 1 ) and B ( 2 ) showed significant cytotoxicity (ED50 0.75–3.50 μg/ml) against ten tumor cell lines. Compound 1 also significantly inhibited the proliferation, migration, and tube formation of human microvascular endothelial cells. |
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| Keywords: | Philinopsides A and B Pentacta quadranyularis Sea cucnumber Gylcosides Triterpenes |
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