Synthesis of 1,2‐Disubstituted Carbocyclic Nucleoside Analogues of Cytidine |
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| Authors: | María&#x;Jos Gonzlez‐Moa Pedro Besada Carmen Tern Lourdes Santana Eugenio Uriarte Dolores Via |
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| Institution: | María?José González‐Moa,Pedro Besada,Carmen Terán,Lourdes Santana,Eugenio Uriarte,Dolores Viña |
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| Abstract: | The synthesis of new 1,2‐disubstituted, five‐ or six‐ring‐carbocyclic nucleoside analogues of cytidine, compounds 1 and 2a – d , are described. These compounds were obtained by aminolysis, starting from the corresponding uracil derivative, via nucleophilic displacement of a triazolyl (Scheme 1) or a (2,4,6‐triisopropylphenyl)sulfonyl (TPS) group (Scheme 2) at 4‐position of the pyrimidine ring. |
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| Keywords: | Nucleosides Cytidine analogues Uracil Nucleophilic substitution |
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