Determination of Amlodipine and Atenolol by Batch Injection Analysis with Amperometric Detection on Boron‐doped Diamond Electrode

This work describes the sequential determination of amlodipine (AML) and atenolol (ATN) by batch injection analysis (BIA) with pulsed amperometric detection (BIA‐PAD). Boron doped diamond (BDD) was used as working electrode. AML was detected at +1.00 V and ATN at +1.65 V. The proposed BIA method is simple, robust, precise (RSD <3.2 %; n=10), presents high analytical frequency (>70 injections h^?1), generates reduced volume of waste (without use of organic solvent) and requires minimal sample manipulation (dissolution and dilution in electrolyte). The limits of detection were 0.074 and 0.073 µmol L^?1 for AML and ATN, respectively. The results obtained with the proposed BIA method were compared to those obtained by HPLC and similar results were obtained (at 95% of confidence level).