Graphene Oxide/ZnO Nano Composite for Sensitive and Selective Electrochemical Sensing of Levodopa and Tyrosine Using Modified Graphite Screen Printed Electrode |
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Authors: | Hadi Beitollahi Fariba Garkani Nejad |
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Institution: | 1. +98?3426226613+98?3426226617;2. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran;3. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran |
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Abstract: | Determination of levodopa and tyrosine as two important species for treatment of Parkinson's disease is described. A novel electrochemical sensor involving graphene oxide/ZnO nanorods (GR/ZnO) nano composite and the graphite screen‐printed electrodes (GSPE) was developed for the simultaneous detection of levodopa and tyrosine. The screen‐printed electrodes with several advantages, including low cost, versatility and miniaturization were employed. On the other hand, the graphene oxide/ZnO nanorods nano composite was casted on the surface of GSPE to obtain GR/ZnO/SPE. The proposed nano sensor has excellent performance such as high sensitivity, good selectivity and analytical application in real samples. The combination of graphene oxide/ZnO nanorods nano composite with the screen‐printed electrode is favorable for amplifying electrochemical signals. Under optimized conditions square wave voltammetry (SWV) exhibited linear dynamic ranges from 1.0×10?6 to 1.0×10?3 M and 1.0×10?6 to 8.0×10?4 M with detection limits of 4.5×10?7 M and 3.4×10?7 M for levodopa and tyrosine respectively. |
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Keywords: | Levodopa Tyrosine Graphene oxide/ZnO nanorods Screen-printed electrodes |
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