Zn-proline catalyzed direct aldol reaction in aqueous media |
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| Authors: | Darbre Tamis Machuqueiro Miguel |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Switzerland. darbre@ioc.unibe.ch |
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| Abstract: | Zn complexes of proline, lysine and arginine are efficient catalysts for the aldol addition of p-nitrobenzaldehyde and acetone in aqueous medium, giving quantitative yields and enantiomeric excesses up to 56% with 5 mol% of the catalysts at room temperature. |
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