Opportune gem‐Silylborylation of Carbonyl Compounds: A Modular and Stereocontrolled Entry to Tetrasubstituted Olefins |
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| Authors: | Enrico La Cascia Dr Ana B Cuenca Dr Elena Fernández |
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| Institution: | Department Química Física i Inorgànica, University Rovira i Virgili, Tarragona, Spain |
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| Abstract: | An easy access to highly versatile gem‐silylboronate synthons is achieved by means of a new olefination reagent, HC(Bpin)2(SiMe3). Subsequent silicon or boron‐based selective functionalization allows for the modular and stereocontrolled synthesis of all‐carbon tetrasubstituted alkenes. A particular attraction of this approach is the iododesilylation reaction, which becomes a pivotal tool for C?Si functionalization. |
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| Keywords: | alkenes gem-silylborylation insertion iododesilylation tamoxifen |
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