Anionic Oligothiophenes Compete for Binding of X‐34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain‐Derived Aβ |
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Authors: | Marcus Bäck Hanna Appelqvist Harry LeVine III K Peter R Nilsson |
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Institution: | 1. Division of Chemistry, Department of Physics, Chemistry and Biology, Link?ping University, Link?ping, Sweden;2. Department Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA |
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Abstract: | Deposits comprised of amyloid‐β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X‐34, a Congo Red analogue, but not Pittsburgh compound B (PIB) from recombinant Aβ amyloid fibrils and Alzheimer's disease brain‐derived Aβ. Overall, we foresee that the oligothiophene scaffold offers the possibility to develop novel high‐affinity ligands for Aβ pathology only found in human AD brain, targeting a different site than PIB. |
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Keywords: | Alzheimer's disease amyloid ligands fluorescence luminescent conjugated oligothiophenes proteins |
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