Unlocking Mizoroki–Heck‐Type Reactions of Aryl Cyanides Using Transfer Hydrocyanation as a Turnover‐Enabling Step |
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Authors: | Dr. Xianjie Fang Peng Yu Gabriele Prina Cerai Dr. Bill Morandi |
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Affiliation: | Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany |
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Abstract: | A new transfer hydrofunctionalization strategy to turnover H‐MII‐X complexes has enabled both intra‐ and intermolecular Mizoroki–Heck (MH)‐type reactions of aryl cyanides that are challenging to realize under traditional, basic conditions. Initially, a cascade carbonickelation/MH reaction of 2‐cyanostyrenes was achieved using a key alkyne transfer hydrocyanation step. Mechanistic experiments supported the proposed catalytic cycle, including the turnover‐enabling transfer hydrocyanation step. The reactivity was then extended to the intermolecular MH reaction of benzonitriles and styrenes. |
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Keywords: | alkenes alkynes cyanide Mizoroki– Heck transfer hydrofunctionalization |
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