Palladium‐Catalyzed Multi‐Component Reactions of N‐Tosylhydrazones, 2‐Iodoanilines and CO2 towards 4‐Aryl‐2‐Quinolinones |
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| Authors: | Dr. Song Sun Wei‐Ming Hu Ning Gu Prof. Dr. Jiang Cheng |
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| Affiliation: | 1. www.chengjiangjs.com;2. School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou, P. R. China |
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| Abstract: | A palladium‐catalyzed three‐component reaction between N‐tosylhydrazones, 2‐iodoanilines and atmospheric pressure CO2 was developed whereby a tandem carbene migration insertion/lactamization strategy afforded 4‐aryl‐2‐quinolinones in moderate to good yields. Notably, a wide range of functional groups were tolerated in this procedure. This protocol features the simultaneous formation of four novel bonds; two C?C, one C=C and one C?N (amide), representing an efficient methodology for incorporation of CO2 into heterocycles. |
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| Keywords: | 4-aryl-2-quinolinone carbon dioxide fixation heterocycles multi-component reaction N-tosylhydrazone |
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