Orthogonal Synthesis of Xeno Nucleic Acids |
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| Authors: | Guillaume Fiers Dr Dalila Chouikhi Laurence Oswald Dr Abdelaziz Al?Ouahabi Dr Delphine Chan‐Seng Prof Laurence Charles Dr Jean‐François Lutz |
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| Institution: | 1. Precision Macromolecular Chemistry Group, Institut Charles Sadron, Strasbourg Cedex 2, France;2. Laboratoire de Catalyse et Synthèse en Chimie Organique, Université Abou Bekr Belkaid, Tlemcen, Algeria;3. Aix Marseille Univ, CNRS, Institute of Radical Chemistry, Marseille, France |
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| Abstract: | Sequence‐defined peptide triazole nucleic acids (PTzNA) were synthesized by means of a solid‐phase orthogonal “AB+CD” iterative strategy. In this approach, AB and CD building blocks containing carboxylic acid (A), azide (B), alkyne (C), and primary amine (D) functions are assembled together by successive copper‐catalyzed azide–alkyne cycloaddition (CuAAC) and acid–amine coupling steps. Different PTzNA genetic sequences were prepared using a library of eight building blocks (i.e., four AB and four CD building blocks). |
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| Keywords: | iterative chemistry nucleic acids orthogonal synthesis sequence-controlled polymers solid-phase synthesis |
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