Traceless Rhodium‐Catalyzed Hydroacylation Using Alkyl Aldehydes: The Enantioselective Synthesis of β‐Aryl Ketones |
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| Authors: | Anaïs Bouisseau Ming Gao Prof Michael C Willis |
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| Institution: | 1. http://mcwillis.chem.ox.ac.uk/MCW/Home.html;2. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK |
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| Abstract: | A one‐pot three‐step sequence involving Rh‐catalyzed alkene hydroacylation, sulfide elimination and Rh‐catalyzed aryl boronic acid conjugate addition gave products of traceless chelation‐controlled hydroacylation employing alkyl aldehydes. The stereodefined β‐aryl ketones were obtained in good yields with excellent control of enantioselectivity. Good variation of all three reaction components is possible. |
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| Keywords: | boronic acid diene ligands ketones rhodium catalysis tandem reactions |
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