Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis |
| |
| Authors: | Daniel E Hagaman Jossana A Damasco Joy Vanessa D Perez Raniv D Rojo Marites P Melancon |
| |
| Institution: | 1.Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; (D.E.H.); (J.A.D.); (J.V.D.P.); (R.D.R.);2.College of Medicine, University of the Philippines, Manila NCR 1000, Philippines;3.UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA |
| |
| Abstract: | Patients with advanced prostate cancer can develop painful and debilitating bone metastases. Currently available interventions for prostate cancer bone metastases, including chemotherapy, bisphosphonates, and radiopharmaceuticals, are only palliative. They can relieve pain, reduce complications (e.g., bone fractures), and improve quality of life, but they do not significantly improve survival times. Therefore, additional strategies to enhance the diagnosis and treatment of prostate cancer bone metastases are needed. Nanotechnology is a versatile platform that has been used to increase the specificity and therapeutic efficacy of various treatments for prostate cancer bone metastases. In this review, we summarize preclinical research that utilizes nanotechnology to develop novel diagnostic imaging tools, translational models, and therapies to combat prostate cancer bone metastases. |
| |
| Keywords: | prostate cancer bone metastasis nanotechnology nanomedicine |
|
|
