Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-Chao, Inage-Ku, Chiba-Shi, Chiba 263, Japan
Abstract:
High-performance liquid chromatography of glycosaminoglycan (GAG)-derived oligosaccharides has been employed for structural analysis and measurement of hyaluronan, chondroitin sulphate, dermatan sulphate, keratan sulphate, herapan sulphate and heparin. Recent developments in the separation and detection of unsaturated dissacharides and oligosaccharides derived from GAGs by enzyme or chemical degradation are reviewed.