High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments |
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Authors: | Sillen Alain Wieruszeski Jean-Michel Leroy Arnaud Younes Amena Ben Landrieu Isabelle Lippens Guy |
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Affiliation: | CNRS - Université de Lille 2 UMR 8525 and Inserm IFR17, Institut Pasteur de Lille, BP 245 - F-59019 Lille Cedex, France. |
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Abstract: | HRMAS NMR of tau paired helical fragments assembled with heparin show an intensity decrease for those amino acids that are incorporated into the rigid core region, whereas the N-terminal amino acids maintain their full mobility. |
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