Synthese von (22R,25S)-16β-Amino-22,26-epiminocholestanen |
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| Authors: | Dr. Rudolf Franzmair |
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| Affiliation: | (1) Abteilung für Pharmazeutisch-chemische Forschung, Chemie Linz AG, St. Peter-Straße 25, A-4020 Linz, Österreich |
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| Abstract: | By reacting the known 16 -bromo-N-cyano-22,26-epimino-cholestanes (e.g.2) with NaN3 inDMF 16 -azido-N-cyano-22,26-epimino-cholestanes (e.g.4) were obtained. Reduction of4 with LiAlH4 gives 16-amino-22,26-epimino-cholestane (9). Some acylated derivatives of9 are described, e.g. the known derivatives11 and13, which prove the stereochemistry at C-16.
Herrn Prof. Dr.K. Kratzl mit den besten Wünschen zum 60. Geburtstag von der Abteilung für Pharmazeutisch-chemische Forschung der Chemie Linz AG gewidmet. |
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