Asymmetric catalysis by chiral titanium perchlorate for carbonyl-ene cyclization |
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| Authors: | Koichi Mikami Eiji Sawa Masahiro Terada |
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| Institution: | Department of Chemical Technology, Tokyo Institute of Technology, Meguro-ku, Tokyo 152, Japan |
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| Abstract: | The chiral binaphthol-derived titanium perchlorate (or triflate) is shown to serve efficiently as an asymmetric catalyst for the ene cyclization of type {3,4exo,exo} and {2,4exo′,exo} involving  -alkoxy aldehyde as an internal enophile to afford the 6- and 7- membered cyclic ethers in high enantiomeric purity. |
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