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Chemically programmed supramolecular assembly of hemoprotein and streptavidin with alternating alignment
Authors:Oohora Koji  Burazerovic Sabina  Onoda Akira  Wilson Yvonne M  Ward Thomas R  Hayashi Takashi
Affiliation:Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan.
Abstract:Alternating: a cofactor dyad consisting of a heme group (red in picture) and a bis(biotin) unit (blue) was synthesized and shown to specifically bind to both apomyoglobin and streptavidin. In the presence of the dyad, the 1:1 association of a disulfide-bridged myoglobin dimer (green) with streptavidin (gray) afforded a submicrometer-sized fibrous alternating copolymer.
Keywords:heme proteins  protein assembly  streptavidin  supramolecular chemistry  supramolecular copolymer
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