Asymmetric synthesis of 4,8-dihydroxyisochroman-1-one polyketide metabolites using chiral hypervalent iodine(III) |
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| Authors: | Fujita Morifumi Mori Kazuhiro Shimogaki Mio Sugimura Takashi |
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| Affiliation: | Graduate School of Material Science, University of Hyogo, Kohto, Kamigori, Hyogo 678-1297, Japan. fuji@sci.u-hyogo.ac.jp |
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| Abstract: | Stereoselective oxylactonization of ortho-alkenylbenzoate with chiral hypervalent iodine is applied to the asymmetric synthesis of 4-oxyisochroman-1-one polyketide metabolites including 4-hydroxymellein (1), a derivative of fusarentin 2, monocerin (3), and an epimer of monocerin epi-3. |
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