Enantioselective gold-catalyzed synthesis of polycyclic indolines |
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| Authors: | Cera Gianpiero Chiarucci Michel Mazzanti Andrea Mancinelli Michele Bandini Marco |
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| Affiliation: | Department of Chemistry, G. Ciamician, Alma Mater Studiorum - University of Bologna, via Selmi 2, 40126 Bologna, Italy. |
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| Abstract: | The synthesis of architecturally complex polycyclic fused indolines is achieved in a chemo-, regio-, and stereodefined manner, via an enantioselective gold-catalyzed cascade hydroindolination/iminium trapping synthetic sequence. Highly functionalized tetracyclic fused furoindolines (2) and dihydropyranylindolines (4) are synthesized in moderate to good yields and enantiomeric excesses of up to 87%. |
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