Proton relaxation enhancement by manganese(III)TPPS4 in a model tumor system |
| |
| Authors: | R J Fiel T M Button S Gilani E H Mark D A Musser R M Henkelman M J Bronskill J G van Heteren |
| |
| Affiliation: | 1. Biocomplexity Institute, Indiana University, Bloomington, IN, USA;2. Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA;3. Department of Physics, Indiana University, Bloomington, IN, USA;4. Scientific Designs, Indianapolis, IN, USA;5. Department of Medicine, Indiana University, Indianapolis, IN, USA;6. School of Public Health, Indiana University, Bloomington, IN, USA;1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia;2. Substance Abuse Research Center, Jazan University, Jazan 45142, Saudi Arabia;4. Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany;5. Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt |
| |
| Abstract: | Managanese(III)tetraphenylporphine sulfonate [Mn(III)TPPS4] has been investigated as a tumor specific paramagnetic contrast agent for magnetic resonance imaging (MRI) of L1210 solid tumors in mice. Mn(III)TPPS4 was found to clear rapidly from the blood and concentrate in the kidneys, tumor and liver. Although relatively high ratios of tumor to normal tissues could be obtained (e.g., greater than 90 for tumor/muscle), the kidneys were found to have the highest concentration of the metalloporphyrin at all doses and time periods tested. A significant decrease in the longitudinal relaxation time was measured for excised tissues (kidney, tumor, liver, muscle) from mice that were treated with Mn(III)TPPS4. A linear correlation was observed between the longitudinal relaxation rate determined for L1210 tumor and the corresponding concentration of Mn(III)TPPS4 found at various injected doses and time intervals between the injection and analysis. A small animal radiofrequency receiver coil designed for use with a 0.15-T clinical imager was employed to evaluate the ability of Mn(III)TPPS4 to selectively increase the signal intensity of the implanted L1210 tumor. The images show a conspicuous enhancement in the contrast between the tumor and adjacent tissue upon treatment with this agent. The results indicate that Mn(III)TPPS4 is a useful prototype paramagnetic metalloporphyrin MRI contrast agent with a significant affinity for the L1210 tumor. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
