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The enantiospecific synthesis of (4S,5R)-and (4S,5S)-4,5-dihydroxydecanoic acid γ-lactones,proposed autoregulators from Streptomyces griseus
Authors:Roderick D Cooper  Veerappa B Jigajinni  Richard H Wightman
Institution:Department of Chemistry, Heriot-Watt University, Riccarton, Edinburgh, EH14 4AS, Scotland.
Abstract:Both the (4S,5R)- and (4S,5S)-isomers of 4,5-dihydroxydecanoic acid γ-lactone, natural products and proposed autoregulators of Streptomyces Griseus, have been synthesised directly and in high yield from D-ribose via a common intermediate.
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